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Oral semaglutide does not interact with any of the major cytochrome P450 isoforms, indicating a low likelihood for drug-drug interactions. Oral semaglutide does not appear to affect the metabolism of warfarin, however regular monitoring of INR is recommended for those on warfarin after starting the treatment. If your patient reported warfarin use in their screening questionnaire, we have asked them to arrange this. It is important that participants taking thyroxine continue to undergo regular checks of their thyroid function tests.