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Oral semaglutide causes nausea and diarrhoea in about one in ten patients. This usually resolves over time, and dietary changes can help. Severe gastrointestinal side effects may rarely cause dehydration. 

Co-administration with insulin and/or sulphonylurea therapy may increase the risk of hypoglycaemia. If your patient reports symptomatic hypoglycaemia, please consider a reduction in sulphonylurea or insulin dose. You can contact the ASCEND PLUS team for advice.